A simple, precise, specific and accurate reverse phase HPLC method has been developed for the simultaneous estimation of enalapril maleate (EM) and metformin hydrochloride (MT). The chromatographic separation was achieved on Phenomenex Luna C18 (25 cm × 4.6 mm i.d., 5 µ) column using PDA detector. The mobile phase consisting of mixture of acetonitrile - 10mM NaH2PO4 (pH 2.2, adjusted with 80 % O–phosphoric acid) (30:70, v/v) at a flow rate of 1.0 ml/min was used. The method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.
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